Telomeres shorten during ageing of human fibroblasts pdf

It is not known whether this loss of DNA has a causal role in senescence. Telomeres Shorten during Aging of Human Fibroblasts.

DOI: More information and software credits. Futcher, Bruce Greider, Carol. Food and Drug Administration. Telomere Learning Center TLC is the definitive online library of news and scientic research on telomere health. More Learning Center Articles.

Telomeres shorten during ageing of human fibroblasts Telomeres » Institutional Study » Telomeres shorten during ageing of human fibroblasts. Leave a Reply Cancel reply Your email address will not be published. Cell Res.

Mild hyperoxia shortens telomeres and inhibits prolifer- ation of fibroblasts: a model for senescence? Cellular and molecular mechanisms of stress-induced pre- mature senescence SIPS of human diploid fibroblasts and melanocytes.

Ger- ontol. Telomeres shorten during ageing of human fibroblasts. Nature — Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor?

Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell — Normal human chromosomes have long G-rich telomeric overhangs at one end. Telomere loss: mitotic clock or time bomb? Evidence for a critical telomere length in senescent human fibroblasts. Extension of life-span by introduction of telomerase into normal human cells. Science — Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype.

BJ fibroblasts display slow telomere shortening independent of hTERT transfection due to high antioxidant capacity. Free Radic. Similar gene expression pattern in senescent and hyperoxic treated fibroblasts. A Biol. Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts.

Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Accelerated telomere shortening in fibroblasts after extended periods of confluency.

Role of oxidative stress in telomere length regulation and rep- licative senescence. Mammalian telomeres end in a large duplex loop. Po1, the putative telomere end-binding protein in fission yeast and humans. Telomere shortening triggers a pdependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments. Oncogene — Telomere states and cell fates. Nature 53— Ribozyme cleavage of telomerase mRNA sensitizes breast tumor cells to inhibitors of topoisomerase.

Cancer Res. Ribozyme-mediated telomerase inhibition induces immedi- ate cell loss but not telomere shortening in ovarian cancer cells. Cancer Gene Ther. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoetic stem cells and memory T cells in early childhood.

Genetic determination of telomere size in humans: a twin study of three age groups. Telomere length as a marker of oxidative stress in primary human fibroblast cultures. Advanced telomere shortening in respiratory chain disorders. Loss of telomeric DNA during ageing of normal and trisomie 21 human lymphocytes. Telomere length in different tissues of elderly patients.